Some studies suggest people with blood type O may have a lower risk of cancers compared to other blood groups, possibly due to differences in inflammation and immune response, but overall risk depends on many factors like genetics and lifestyle.

The relationship between blood type and cancer risk may also involve inflammation, which plays a major role in the development of many chronic diseases. People with different blood types can have varying levels of certain clotting factors and inflammatory markers in their bloodstream. For example, individuals with non-O blood types tend to have higher levels of von Willebrand factor, a protein involved in blood clotting. Elevated levels of such factors have been associated with increased risks of cardiovascular disease and may also contribute to environments where cancer cells can thrive. This suggests that the biological mechanisms tied to blood type extend far beyond simple classification.

Another possible explanation lies in how blood type influences interactions with bacteria and viruses. Certain pathogens appear to bind more easily to specific blood group antigens, which may lead to chronic infections or prolonged inflammation—both of which can increase cancer risk over time. For instance, some research has examined how blood type may affect susceptibility to Helicobacter pylori infection, a bacterium linked to stomach cancer. If certain blood types are more prone to persistent infection, this could partly explain differences in cancer rates observed across populations. Still, these findings are complex and often vary between studies.

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